Crews were on the scene of a crash near the connector at Interstate 70 and Highway 63 in Columbia.
The crash reportedly happened just after 8:00 Tuesday morning.
At least five units responded to the scene.
ABC 17 News is hearing reports that one vehicle involved may have caught on fire in the crash. Police have not confirmed this yet.
Crews had cleared the scene by 8:30 a.m.
ABC 17 News is working to find out if any lanes were blocked and if anyone was injured.